BODIPY-coelenterazine conjugates as self-illuminating substrates for NanoLuc

Viereckt, V.; Abendroth, F.; Schauerte, A.; Gerhard, M.; Lichtenberg, C.; Kosenkov, D.; Vázquez, O.*

Chem Commun 2025, 61, 5190-51-93
BODIPY-coelenterazine conjugates as self-illuminating substrates for NanoLuc

Short internal open reading frames repress the translation of N-terminally truncated proteoforms

Fettig, R.; Gonda, Z.; Walter, N.; Sallmann, P.; Thanisch, C.; Winter, M.; Bauer, S.; Zhang, L.; Linden, G.; Litfin, M.; Khamanaeva, M.; Storm, S.; Münzing, C.; Etard, C.; Armant, O.; Vázquez O.;  Kassel, O.*

EMBO Rep. 2025, 26, 1566-1589
Short internal open reading frames repress the translation of N-terminally truncated proteoforms

Development of mirror-image monobodies targeting the oncogenic BCR::ABL1 kinase

Schmidt, N.; Kumar, A.; Korf, L.; Dinh-Fricke, A. V.; Abendroth, F.; Koide, A.; Linne, U.; Rakwalska-Bange, M.; Koide, S.; Essen, L. O.; Vázquez, O.*; Hantschel, O.*

Nat Commun. 2024, 52, 15, 10724

Highlighted in the cover page of Marburg University https://www.uni-marburg.de/de/aktuelles/news/2025/spiegelverkehrte-proteine

 		Development of mirror-image monobodies targeting the oncogenic BCR::ABL1 kinase
Development of mirror-image monobodies targeting the oncogenic BCR::ABL1 kinase

Proton tunneling allows a proton-coupled electron transfer process in the cancer cell

Zhang, T.; Ghosh, A.; Behringer-Pließ, L.; Chouhan, L.; Cunha, A. V.; Havenith, R. W. A; Butkevich, E.; Zhang, L.; Vázquez, O.; Debroye, E.; Enderlein, J.; Das, S.*

JACS Au. 2024, 4, 4856 – 4865
Proton tunneling allows a proton-coupled electron transfer process in the cancer cell

ZNF512B binds RBBP4 via a variant NuRD interaction motif and aggregates chromatin in a NuRD complex-independent manner

Wunderlich, T. M.; Deshpande, C.; Paasche, L. W.; Friedrich, T.; Diegmüller, F.; Haddad, E.; Kreienbaum, C.; Naseer, H.; Stebel, S. E.; Daus, N.; Leers, J.; Lan, J.; Trinh, V. T.; Vázquez, O.; Butter, F.; Bartkuhn, M.; Mackay, J. P.; Hake, S. B.*

Nucleic Acids Res. 2024, 52, 12831 – 12849
ZNF512B binds RBBP4 via a variant NuRD interaction motif and aggregates chromatin in a NuRD complex-independent manner

A virtual library of small molecules mimicking dipeptides

Lim, V. J. Y.; Gerber, H. D.; Schihada, H.; Trinh, V. T.; Hilger, D.; Vázquez, O.; Kolb, P.*

Arch. Pharm. (Weinheim) 2024, 357, e2300636
A virtual library of small molecules mimicking dipeptides

Enlightening epigenetics: optochemical tools illuminate the path

Su, K.; Vázquez, O.*

Trends Biochem. Sci., 2024, 49, 290 – 304
Enlightening epigenetics: optochemical tools illuminate the path

Cell-free biosynthesis combined with deep learning accelerates de novo-development of antimicrobial peptides

Pandi, A.*; Adam, D.; Zare, A.; Trinh, V.T.; Schaefer, S.L.; Burt, M.; Klabunde, B.; Bobkova, E.; Kushwaha, M.; Foroughijabbari, Y.; Braun, P.; Spahn, C.; Preußer, C.; Pogge von Strandmann, E.; Bode, H.B.; von Buttlar, H.; Bertrams, W.; Jung, A.L.; Abendroth, F.; Schmeck, B.; Hummer, G.; Vázquez, O.; Erb, T.J* 

Nat Commun, 2023, 14, 7197-7211
Cell-free biosynthesis combined with deep learning accelerates de novo-development of antimicrobial peptides

Peptide-mediated inhibition of the transcriptional regulator Elongin BC induces apoptosis in cancer cells

Fischer, S#; Trinh, V. T.#; Simon, C.; Weber, L. M.; Forné, I.; Nist, A. Bange, G.; Abendroth, F.; Stiewe, T.; Steinchen, W.; Liefke, R*. Vázquez, O.*; ( # Equal 1st author contribution)

Cell Chem. Bo, 2023, 30, 766-779

Reported in:

  • Marburg University (23.06.2023)
  • Hessenshau (28.06.2023)
  • Mediziner Aspekete (23.06.2023)
Peptide-mediated inhibition of the transcriptional regulator Elongin BC induces apoptosis in cancer cells

Reversible Control of RNA Splicing by Photoswitchable Small Molecules

Zhang, L.; Xiulan X.; Djokovic N.; Nikolic, K.; Kosenkov, D.; Abendroth, F.*; Vázquez, O*

J. Am Chem. Soc. 145, 12783-12792

Reversible Control of RNA Splicing by Photoswitchable Small Molecules

EFMC: Trends in Medicinal Chemistry and Chemical Biology

Auberson, P.Y.*, Arimondo, P. B.; Duca, M.; Essig, S.; Grether, U.; Rufer, A. C.; Sbardella, G.; Shopfer, U.; Torrens, A.; van der Stelt, M; Vauzeilles, B.; Vázquez, O.; Zhang, A. X.

 Chem.Bio. 2023, 24, e20220069
EFMC: Trends in Medicinal Chemistry and Chemical Biology

Synthesis of the L- and D-SH2 domain of the leukaemia oncogene Bcr-Abl

Schmidt, N.; Abendroth, F.; Vázquez, O.*, Hantschel, O.*

RSC Chem. Biol., 2022, 3, 1008-1012
Synthesis of the L- and D-SH2 domain of the leukaemia oncogene Bcr-Abl

Increasing the efficiency of hyperthermic intraperitoneal chemotherapy (HIPEC) by a combination with a photosensitive drug in pediatric rhabdomyosarcoma

Wagner, B.; Adamus, A.; Hempfling, L., Vahdad, R.; Haap-Hoff, A.; Heinrich, B.; Vázquez, O.; Jank, P.; Denkert, C.; Seitz, G*

Pediatr. Blood Cancer, 2022, 11, e29864
Increasing the efficiency of hyperthermic intraperitoneal chemotherapy (HIPEC) by a combination with a photosensitive drug in pediatric rhabdomyosarcoma

A chemical biology perspective to therapeutic regulation of RNA splicing in spinal muscular atrophy (SMA)

Zhang, L.; Abendroth, F.; Vázquez, O.*

ACS. Chem. Biol., 2022, 17, 1293 -1307
A chemical biology perspective to therapeutic regulation of RNA splicing in spinal muscular atrophy (SMA)

RNA inhibits dMi-2/CHD4 chromatin binding and nucleosome remodeling and nucleosome remodeling

Ullah I.; Thoelken, C.; Zhong, Y.; John, M.; Rossbach, O.; Lenz, J.;Großringer, M.; Nist, A.; Stiewe, T.; Hartmann, R.; Vázquez, O.; Chung,H.-R; Machkay, J.P.; Brehm, A.*

Cell. Rep., 2022, accepted,
RNA inhibits dMi-2/CHD4 chromatin binding and nucleosome remodeling and nucleosome remodeling

Bistable photoswitch allows in vivo control of hematopoiesis

Albert, L.; Nagpal, J.; Steinchen, W.; Zhang, L.; Werel, L.; Djokovic N.; Ruzic, D.; Hoffarth, M.; Xu, J.; Kaspareit, J.; Abendroth, F.; Royant, A.; Bange, G.; Nikolic, K.; Ryu, S.; Dou, Y.; Essen, L.-O.; Vázquez, O*

ACS Cent. Sci, 2022, 8 ,57-66
Bistable photoswitch allows in vivo control of hematopoiesis

Efficient antisense inhibition reveals microRNA-155 to restrain a latemyeloid inflammatory programme in primary human phagocytes

Linden, G.; Harshavardhan, J.; Matthias, F.; Nist, A.; Stiewe, T.; Schmeck B.; Vázquez, O*.; Shulte, L. N.*

RNA Biol., 2021, 18 ,604-618
Efficient antisense inhibition reveals microRNA-155 to restrain a latemyeloid inflammatory programme in primary human phagocytes

Targeted protein degradation as a promising tool for epigenetic upregulation of fetal hemoglobin

Verheul, T. C. J.; Trinh, V. T.; Vázquez, O.* ; Philipsen, S*

MedChemMed, 2020, 15, 2436-2443

Contribution to the Special Chemical Epigenetics Themed Issue in ChemMedChem

 		Targeted protein degradation as a promising tool for epigenetic upregulation of fetal hemoglobin
Targeted protein degradation as a promising tool for epigenetic upregulation of fetal hemoglobin

Ush-regulates hemocyte-specific gene expression, fatty acid metabolism and cell cycle progression and cooperates with dNuRD to orchestrate hematopoiesis

Lenz, J.; Liefke, R.; Funk, S. F.; Shoup, S.; Nist, A.; Stiewe, T.; Schulz, R.; Tokusumi, Y.; Albert L.; Raifer, H.; Förstemann,K.; Vázquez, O.; Tokusumi,T; Fossett; N.; Brehm, A.*

PLoS Genet., 2021, 17, e1009318
Ush-regulates hemocyte-specific gene expression, fatty acid metabolism and cell cycle progression and cooperates with dNuRD to orchestrate hematopoiesis

Bioorthogonal turn-on BODIPY-peptide photosensitizers for tailored photodynamic therapy

Linden, G.; Vázquez, O.*

Chemistry, 2020, 26, 10014-10023

Contribution to the Special Young Chemists 2020 Themed Issue in Chemistry-A European Journal
Bioorthogonal turn-on BODIPY-peptide photosensitizers for tailored photodynamic therapy

Spicing up an interdisciplinary chemical biology course with the authentic big picture of epigenetic research

Heinrich, B.; Graulich, N; Vázquez, O.*

J. Chem. Educ.., 2020, 97, 1316-1326

ACS Editor’s Choice
Spicing up an interdisciplinary chemical biology course with the authentic big picture of epigenetic research

4-Methyltrityl-protected pyrrole and imidazole building blocks for solid phase synthesis of DNA-binding polyamides

Heinrich, B.; Vázquez, O.*

Org. Lett., 2020, 22, 533-536
4-Methyltrityl-protected pyrrole and imidazole building blocks for solid phase synthesis of DNA-binding polyamides

In search of visible-light photoresponsive peptide nucleic acids (PNAs) for reversible control of DNA hybridization

Zhang, L.; Linden, G.; Vázquez, O.*

Beilstein J. Org. Chem., 2019, 15, 2500-2508

Contribution to the Special Molecular Switches Themed Issue in Beilstein Journal of Organic Chemistry
In search of visible-light photoresponsive peptide nucleic acids (PNAs) for reversible control of DNA hybridization

Photoswitchable peptides for spatiotemporal control of biological functions

Albert, L.; Vázquez, O.*

Chem. Commun., 2019, 55, 10192-10213

Contribution to the Special Emerging Investigators Themed Issue in Chemical Communications
Photoswitchable peptides for spatiotemporal control of biological functions

Conditional singlet oxygen generation via DNA-targeted tetrazine bioorthogonal reaction

Linden, G.; Zhang, L.; Pieck, F.; Linne, U.; Kosenkov, D.; Tonner, R.; Vázquez, O.*

Angew. Chem. Int. Ed. Engl. , 2019, 58,12868-12873

Highlight as a Hot Paper

Reported in local press (Oberhessische Presse, 16.09.2019)

Marburg University (09.09.2019)

Journal of Onkologie (26.09.2019)

Journal Chemiextra (11.2019)

 		Conditional singlet oxygen generation via DNA-targeted tetrazine bioorthogonal reaction
Conditional singlet oxygen generation via DNA-targeted tetrazine bioorthogonal reaction

Modulating protein-protein interactions with visible-light responsive peptide backbone photoswitches

Albert, L.; Peñalver, A.; Djokovic, N.; Were, L.; Hoffarth, M.; Ruzic, D.; Xu, J.; Essen, L.-O.; Nikolic, K.; Dou, Y.; Vázquez, O.*

ChemBioChem, 2019, 20, 1417-1429.

Contribution to the Special ChemBioTalents Themed Issue in ChemBioChem

2019 top downloaded ChemBioChem papers

 		Modulating protein-protein interactions with visible-light responsive peptide backbone photoswitches
Modulating protein-protein interactions with visible-light responsive peptide backbone photoswitches

ortho-Fluoroazobenzene derivatives as DNA intercalators for photocontrol of DNA and nucleosome binding by visible light

Heinrich, B.; Bouazoune, K.; Wojcik, M.; Bakowsky, U.; Vázquez, O.*

Org. Biomol. Chem., 2019, 17, 1827-1833

Contribution to the Special New Talent Themed Issue in Organic & Biomolecular Chemistry
ortho-Fluoroazobenzene derivatives as DNA intercalators for photocontrol of DNA and nucleosome binding by visible light

A Far-red fluorescent DNA binder for interaction studies of live multidrug-resistant pathogens and host cells

Schulte, L. N.; Heinrich, B.; Janga, H.; Schmeck, B. T.; Vázquez, O.*

Angew. Chem. Int. Ed. Engl., 2018, 57, 11564-11568
A Far-red fluorescent DNA binder for interaction studies of live multidrug-resistant pathogens and host cells

Controlled inhibition of methyltransferases using photoswitchable peptidomimetics: towards an epigenetic regulation of leukemia

Albert, L.; Xu, J.; Wan, R.; Srinivasan, V.; Dou, Y. Vázquez, O.*

Chem. Sci., 2017, 8, 4612-4618
Controlled inhibition of methyltransferases using photoswitchable peptidomimetics: towards an epigenetic regulation of leukemia

Potential of proapoptotic peptides to induce formation of giant plasma membrane vesicles with lipide domains

Lauster, D.; Vázquez, O.; Schwarzer, R.; Herrmann, A.; Seitz, O. *

ChemBioChem., 2015, 16, 1288-1292
Potential of proapoptotic peptides to induce formation of giant plasma membrane vesicles with lipide domains

Cytotoxic peptide-PNA conjugates by RNA-programmed peptidyl transfer with turnover

Vázquez, O.; Seitz, O. *

Chem Sci., 2014, 5, 2850-2854
Cytotoxic peptide-PNA conjugates by RNA-programmed peptidyl transfer with turnover

Templated native chemical ligation: peptide chemistry beyond protein synthesis

Vázquez, O.; Seitz, O *

J. Pept., 2014, 20, 78-86

Templated native chemical ligation: peptide chemistry beyond protein synthesis

The ββα fold of zinc finger proteins as a “natural” protecting group. Chemoselective synthesis of a DNA-binding zinc finger derivative

Rodríguez, J.; Mosquera, J.; Vázquez, O.; Vázquez, M. E.; Mascareñas J. L. *

Chem. Commun, 2014, 50, 2258-2260
The ββα fold of zinc finger proteins as a “natural” protecting group. Chemoselective synthesis of a DNA-binding zinc finger derivative

Sequence-selective DNA recognition with peptide-bisbenzamidine conjugates

Sánchez, M. I.; Vázquez, O.; Vázquez, M. E.; Mascareñas J. L. *

Chem. Eur. J., 2013, 19, 9923-9929
Sequence-selective DNA recognition with peptide-bisbenzamidine conjugates

Straightforward access to bisbenzamidine DNA binders and their use as versatile adaptors for DNA-promoted processes

Sánchez, M. I.; Vázquez, O.; Martínez-Costas, J.; Vázquez, M. E.; Mascareñas J. L *

Chem. Sci, 2012, 3, 2383-2387
Straightforward access to bisbenzamidine DNA binders and their use as versatile adaptors for DNA-promoted processes

Light-controlled DNA binding of bisbenzamidines

Sánchez, M. I.; Vázquez , O.; V?zquez. M. E.; Mascareñas, J.L. *

Chem. Commun., 2011, 47, 11107-11109
Light-controlled DNA binding of bisbenzamidines

dsDNA-triggered energy transfer and lanthanide sensitization processes

Vázquez , O.; Sánchez, M. I.; Vázquez. M. E.; Mascareñas, J.L. *

Chem. Commun., 2010, 46, 5518-5520
dsDNA-triggered energy transfer and lanthanide sensitization processes

Bis-4-aminobenzamidines: versatile, fluorogenic A/T selective dsDNA binders

Vázquez, O.; Sánchez, M. I.; Martínez Costas, J.; Vázquez. M. E.; Mascareñas, J.L. *

Org. Lett. 2010, 12, 216-219
Bis-4-aminobenzamidines: versatile, fluorogenic A/T selective dsDNA binders

Peptide-based fluorescent biosensors.

Pazos, E.; Vázquez, O. Mascareñas, J. L. *; Vázquez, M. E *

Chem. Soc. Rev. 2009, 38, 3348-3359
Peptide-based fluorescent biosensors.

Efficient DNA binding and nuclear uptake by distamycin derivates conjugated to octa-arginine sequences

Vázquez, O.; Blanco, J.B; Vázquez, M. E.; Martinez-Costas, J. Castedo, L.; Mascareñas, J.L. *

ChemBioChem. 2008, 9, 2822-2829
Efficient DNA binding and nuclear uptake by distamycin derivates conjugated to octa-arginine sequences

Specific DNA recognition by a synthetic, monomeric Cys2His2 zinc finger peptide conjugated to a minor groove binder

Vázquez, O.; Vázquez, M. E.; Blanco, J. B.; Castedo, L.; Mascareñas, J.L. *

Angew. Chem. Int. Ed. Engl., 2007, 46, 6886–6890
Specific DNA recognition by a synthetic, monomeric Cys2His2 zinc finger peptide conjugated to a minor groove binder

High affinity, sequence specific DNA-binding by synthetic tripyrrole-peptide conjugates

Blanco, J.B; Vázquez, O.; Martinez-Costas, J.; Castedo, L.; Mascareñas, J.L *

Chem. Eur. J. 2005, 11, 4171-4178
High affinity, sequence specific DNA-binding by synthetic tripyrrole-peptide conjugates

Structure of the ATP-driven methyl-coenzyme M reductase activation complex
Structure of the ATP-driven methyl-coenzyme M reductase activation complex

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