Research

The passion for studying life by chemistry!

Our multidisciplinary research strives to understand biological processes at the molecular level to elucidate the fundamental problems at the interface of chemistry and biology. For this purpose, we focus on the design and development of innovative chemical tools for sensing biological processes and remotely manipulate molecular machines inside cells. Our work embraces the synthesis of low molecular weight drug-like molecules, peptides and nucleic acids combined with the methodology to investigate physiological responses. Thus, our optochemical tools have been able of achieving conditional and selective biological modulation by taking full advantage of photosensitive molecules



Fluorophores
Our  far-red compound 6-TramTO-3 enables fast and reliable fluorescent labelling of multi-resistant bacteria without  genetic modification. Angew. Chem. Int. Ed. Engl., 2018, 57, 11564
Filed Patents: EP18174086.1
EP21192451.9  
Photoswitches
Our photoswitches work as either optoepigenetic tools to reversibly photomodulate epigenetic player such as histone methyltransferases or reversible splicing modifiers.
Chem. Sci., 2017, 8, 4612  
ACS Cent. Sci. 2022, 8, 57
J. Am. Chem. Soc.
2023, 145, 12783
Photosensitizers
Our novel halogenated BODIPY‐tetrazine probes simultaneously allows specific subcellular localization  and conditional singlet oxygen generation.
Angew. Chem. Int. Ed. Engl. 2019, 58, 12868
Chemistry2020, 26, 10014

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Meet our Team

Our passionate team makes the magic happen!
Ina Pinnschmidt
Ina Pinnschmidt

Administrative Assistant


Room: C104 (01/3040)
Tel: +49 6421 28 21535
Fax: +49 6421 28 22189

Frank Abendroth
Frank Abendroth

ChemBio Platform Head


Room: C 152 (01/3520)
Tel: +49 6421 28 25701
Senior Scientist & Lab Manager

Van Tuan Trinh (Marco)
Van Tuan Trinh (Marco)

PhD Student


Room: D264 (02/4640)
Tel: +49 6421 28 21819
Interests: peptides & epigenetics

Albert Gandioso Ubieto
Albert Gandioso Ubieto

Humboldt Fellow


Room: D264 (02/4650)
Tel: +49 6421 28 22747
Interests: photocages

Raúl Gutiérrez Manzanares
Raúl Gutiérrez Manzanares

PhD Student


Room: D264 (02/4650) Tel: +49 6421 28 22747 Interests: photoswitches

Chiara Giubileo
Chiara Giubileo

Master Student


Room: D264 (02/4650)
Tel: +49 6421 28 22747
Interests: bioluminescence

Finn Höeg
Finn Höeg

PhD Student


Room: D264 (02/4640) Tel: +49 6421 28 22748 Interests: RNase E inhibition

Valeska Viereckt
Valeska Viereckt

PhD Student


Room: D264 (02/4640)
Tel: +49 6421 28 22748
Interests: photosensitizers

Kaijun Su
Kaijun Su

PhD Student


Room: D264 (02/4640)
Tel: +49 6421 28 22747
Interests: protein degradation

Lars-Simon Henkell
Lars-Simon Henkell

Bachelor Student


Room: D264 (02/4640) Tel: +49 6421 28 22747 Interests: photosensitizers

Xabier Jiménez de Aberasturi
Xabier Jiménez de Aberasturi

Visiting Student


Room: D264 (02/4640)
Tel: +49 6421 28 22747
Interests: bioorthogonal reactions

Tim Beunings
Tim Beunings

Bachelor Student


Room: D264 (02/4640) Tel: +49 6421 28 22747 Interests: protein degradation

Address
Fachbereich Chemie Philipps-Universität Marburg Hans-Meerwein-Straße 4, Second floor D 233 (02/4330) 35043 Marburg Germany

Phone & Email
E-mail: olalla.vazquez@staff.uni-marburg.de Phone: +49-6421-28-22745