Research

The passion for studying life by chemistry!

Our multidisciplinary research strives to understand biological processes at the molecular level to elucidate the fundamental problems at the interface of chemistry and biology. For this purpose, we focus on the design and development of innovative chemical tools for sensing biological processes and remotely manipulate molecular machines inside cells. Our work embraces the synthesis of low molecular weight drug-like molecules, peptides and nucleic acids combined with the methodology to investigate physiological responses. Thus, our optochemical tools have been able of achieving conditional and selective biological modulation by taking full advantage of photosensitive molecules



Fluorophores
Our  far-red compound 6-TramTO-3 enables fast and reliable fluorescent labelling of multi-resistant bacteria without  genetic modification. Angew. Chem. Int. Ed. Engl., 2018, 57, 11564
Filed Patents: EP18174086.1
EP21192451.9  
Photoswitches
Our optoepigenetic tools reversibly photomodulate either histone methyltransferase activity or nucleosome assembly.
Chem. Sci., 2017, 8, 4612  
ACS Cent. Sci. 2022, 8, 57
Photosensitizers
Our novel halogenated BODIPY‐tetrazine probes simultaneously allows specific subcellular localization  and conditional singlet oxygen generation.
Angew. Chem. Int. Ed. Engl. 2019, 58, 12868
Chemistry2020, 26, 10014

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Meet our Team

Our passionate team makes the magic happen!
Ina Pinnschmidt
Ina Pinnschmidt

Administrative Assistant


Room: C104 (01/3040)
Tel: +49 6421 28 21535
Fax: +49 6421 28 22189

Van Tuan Trinh (Marco)
Van Tuan Trinh (Marco)

PhD Student


Room: D264 (02/4640)
Tel: +49 6421 28 21819
Interests: peptides & epigenetics

Albert Gandioso Ubieto
Albert Gandioso Ubieto

Humboldt Fellow


Room: D264 (02/4650)
Tel: +49 6421 28 22747
Interests: photocages

Lei Zhang
Lei Zhang

PhD Student


Room: D264 (02/4640)
Tel: +49 6421 282 2748
Interests: photoswitches & photosensitizers

Orlando De Azevedo
Orlando De Azevedo

Postdoctoral Researcher

Room: D264 (02/4640)
Tel: +49 6421 28 22748 Interests: photoswitches

Valeska Viereckt
Valeska Viereckt

PhD Student


Room: D264 (02/4640)
Tel: +49 6421 28 22748
Interests: photosensitizers

Kaijun Su
Kaijun Su

PhD Student


Room: D264 (02/4640)
Tel: +49 6421 28 22747
Interests: protein degradation

Lars-Simon Henkell
Lars-Simon Henkell

Bachelor Student

 
Room: D264 (02/4640)
Tel: +49 6421 28 22747 Interests: photosensitises

Address
Fachbereich Chemie Philipps-Universität Marburg Hans-Meerwein-Straße 4, Second floor D 233 (02/4330) 35043 Marburg Germany

Phone & Email
E-mail: olalla.vazquez@staff.uni-marburg.de Phone: +49-6421-28-22745