Description

Together with Dr. Frank Abendroth, our cutting-edge research platform aims to support UMR groups and researchers beyond by providing unique solutions to their particular scientific challenges. Thus, our ChemBio platform is committed to advancing chemical biology research through innovation. A close collaboration with regular updates and discussions will take place during the whole process and, therefore, authorship contribution is expected.

Scope:
We cover custom development, optimization, and evaluation of:

  • bioactive peptides
  • antisense agents (peptide nucleic acids)
  • custom assays with small molecules or peptides.

Service Structure:
All project requests will be thoroughly assessed and transparently reported to evaluate feasibility before project initiation. We will provide detailed planning including timeline, milestones, and potential challenges. Fees vary based on project scope, complexity, and organization affiliation.


Dr Frank Abendroth

ChemBio Platform Head

A career scientist with over 15 years of experience in chemical biology in academia and industry. 
PhD: Humboldt University (Berlin)- Prof. Oliver Seitz
PostDoc: Career Development Fellow at MRC Laboratory of Molecular Biology, (Cambridge)- Dr. Michael J Gait
ORCID: 0000-0002-0320-2690

What can we do for you?

    Mass calculator for peptide, peptide nucleic acids (PNA) and conjugates

    This tool can calculate various molecular parameters of PNAs, peptides as well as PNA-peptide-conjugates. For the calculation enter the full sequece (separated by spaces) including N- or C-Terminal modifications. Base monomers are all amino acids in single or three letter code (single letters: Caps, three letter code: First letter in upper case, subsequent letters in lower case).
    Note: Building blocks with wrong capitalization like “gly” or “lYs” will not be recognized. To avoid reporting wrong numbers unkown building blocks are replaced by building block “UKN” which has such high values that this should not stay unnoticed.

    • Modifications at the N-terminus
      Modifications at the N-terminus can simply be added as “first” building block,
      like “FAM K C D K G CONH2″ or “TAMRA R C K N N CONH2″
    • Modifications at the C-terminus
      Modifications at the C-terminus can simply be added as “last” building block,
      like “K C D K G COOH ” or “R C K N N CONH2
      Note: While it is not necessary to explicitly declare a free N-terminus it is necessary to add “COOH” as group to denote a free C-terminus!
    • Internal Modifications
      Internal modifications can be added to a building block in round brackets
      like “Lys(FAM) K C D K G COOH” or “Lys(TAMRA) R C K N N COOH”
    • Special Modifications
      Besides typical fluorophores it is possible to use:
      i) “p” to indicate a phosphorylation,
      like “p Tyr”
      ii) the symbol ~ into brackets at a cystein residue to indicate a disulfide bond,
      like “Ac C(~) K G N R C(~) COOH”)

    A full list of building blocks is available here.

    Sequence: