Peptide Inhbitor of Elongin B/C Induces Apoptosis in Cancer Cells Read more Reversible Control of RNA Splicing by Photoswitchable Small Molecules
Check out the 1st author paper of our Marco published in Cell Chemical Biology. Free download for 50 days! Very proud, Marco!Excellent joint project with Robert Liefke and Sabrina Fischer in the frame of our TRR81 Chromatin Changes in Differentiation and Malignancies. Thank you to all collaborators too!! This worked has been highlighted in:– Philipps-Universität […]
Read more EFMC: Trends in Medicinal Chemistry and Chemical Biology
We demonstrated the potential of photopharmacology modulation in splicing, tweaking the current optochemical toolkit. Our work pioneers a reversible approach to regulate RNA splicing within primary patient-derived cells by synthetic photoswitches. Read more here J. Am. Chem. Soc. 2023, accepted You cannot imagine how happy we are and what this means for our small lab!! […]
Read more Cell Report Paper Accepted
Glad to see this paper out!1+1=3 the power of teamwork! A privilege to be able to learn from this brilliant scientists from academia & industry. Thanks to Yves Auberson to take the lead.
Read more ACS Central Science – Accepted!!!
Happy to contribute to this fantastic work of Brehm Lab at Marburg University. Such interaction would not be possible without our TRR81 Chromatin Changes in Differentiation and Malignancies. Congrats to to Ikram & all authors. From our side, credits go to our Lea!
Read more PNAs enable miR-155 inhibition in macrophages
An advanced Xmas present! Our Conformationally Strained Visible light Photoswitches (CS-VIPs) are genuine binary functional switches that enable hematopoisis photocontrol in zebrafish by releasing the chromatin modifier MLL1. An heroic mutidisciplinary effort in pandemic times!! We made it, Lea! Thank you everybody.
Read more PLOS Genetics Paper Is Out!!
We achieve manipulation of primary cells without compromising viability by PNA-conjugates. Check our RNA Biology paper of Greta. Congrats, Greta! Well-deserved! Excellent collaboration with Schulte’s Lab.
Read more ChemMedChem Accepted!
It is a great pleasure to contribute to this brilliant story of Jonathan Lenz & Alexander Brehm. Exciting science arises from our collaborative TRR81 Chromatin Changes in Differentiation and Malignancies
Read more BODIPY-Tetrazine Peptides
Our TRR81 lockdown paper is online! We review the fetal hemoglobin repression network focused on epigenetic repressors that could be targeted by PROTACs. Excellent teamwork with Sjaak Philipsen. Kudos to Thijs & Marco! You can find this article in the Chemical Epigenetics Issue.
Read more Top 10% Most Downloaded Paper!
We are thrilled to share our new paper in Chemistry—An European Journal. We have implemented a peptide‐based platform to prepare, and confine bioorthogonally activatable BODIPY-tetrazine photosensitizers. Check out our cytoplasmic membrane derivative, quite impressive! Congrats to Greta, you rock!
As Whitesides said “Interesting & unpublished is equivalent to non-existent”. We believe that published & unread does not make it any better. We publish to share our findings and achieve a collective advancement in science. Therefore, we are thrilled that our work on photoswitchable protein-protein interaction (PPI) modulators belongs to the 2019 top downloaded ChemBioChem […]