RSC Photochemistry Book Chapter

Here it is our RCS chapter about photoswitchable peptides – a follow-up of Lea’s Chem. Commun 2019 review. We cannot wait to see the actual book. Well-done Marco!! Grateful to Stefano Protti & Stefano Crespi for their understanding & flexibility. We couldn’t commit otherwise.

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Collaboration – Nature Communication

Here, it is!! This is our 1st contribution to antimicrobial peptides under the frame of a collaboration with Tobias Erb & Amir Pandi. From our team kudos go to Frank & Marco. Stay tuned! Marco has another antimicrobial project in the pipeline. Exciting!

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Peptide Inhbitor of Elongin B/C Induces Apoptosis in Cancer Cells

Check out the 1st author paper of our Marco published in Cell Chemical Biology. Free download for 50 days! Very proud, Marco!Excellent joint project with Robert Liefke and Sabrina Fischer in the frame of our TRR81 Chromatin Changes in Differentiation and Malignancies. Thank you to all collaborators too!! This worked has been highlighted in:– Philipps-Universität […]

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Reversible Control of RNA Splicing by Photoswitchable Small Molecules

We demonstrated the potential of photopharmacology modulation in splicing, tweaking the current optochemical toolkit. Our work pioneers a reversible approach to regulate RNA splicing within primary patient-derived cells by synthetic photoswitches. Read more here J. Am. Chem. Soc. 2023, accepted You cannot imagine how happy we are and what this means for our small lab!! […]

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Cell Report Paper Accepted

Happy to contribute to this fantastic work of Brehm Lab at Marburg University. Such interaction would not be possible without our TRR81 Chromatin Changes in Differentiation and Malignancies. Congrats to to Ikram & all authors. From our side, credits go to our Lea!

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ACS Central Science – Accepted!!!

An advanced Xmas present! Our Conformationally Strained Visible light Photoswitches (CS-VIPs) are genuine binary functional switches that enable hematopoisis photocontrol in zebrafish by releasing the chromatin modifier MLL1. An heroic mutidisciplinary effort in pandemic times!! We made it, Lea! Thank you everybody.

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PNAs enable miR-155 inhibition in macrophages

We achieve manipulation of primary cells without compromising viability by PNA-conjugates. Check our RNA Biology paper of Greta. Congrats, Greta! Well-deserved! Excellent collaboration with Schulte’s Lab.

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