4-Methyltrityl-protected pyrrole and imidazole building blocks for solid phase synthesis of DNA-binding polyamides

Heinrich, B.; Vázquez, O.*

Org. Lett., 2020, 22, 533-536


In search of visible-light photoresponsive peptide nucleic acids (PNAs) for reversible control of DNA hybridization

Zhang, L.; Linden, G.; Vázquez, O.*

Beilstein J. Org. Chem., 2019, 15, 2500-2508

Contribution to the Special Molecular Switches Themed Issue in Beilstein Journal of Organic Chemistry


Photoswitchable peptides for spatiotemporal control of biological functions

Albert, L.; Vázquez, O.*

Chem. Commun., 2019, 55, 10192-10213

Contribution to the Special Emerging Investigators Themed Issue in Chemical Communications

Conditional singlet oxygen generation via DNA-targeted tetrazine bioorthogonal reaction

Linden, G.; Zhang, L.; Pieck, F.; Linne, U.; Kosenkov, D.; Tonner, R.; Vázquez, O.*

Angew. Chem. Int. Ed. Engl. 2019, 58,12868-12873

Highlight as a Hot Paper
Reported in local press (Oberhessische Presse, 16.09.2019)
Marburg University (09.09.2019)
Journal of Onkologie (26.09.2019)
Journal Chemiextra (11.2019)



Modulating protein-protein interactions with visible-light responsive peptide backbone photoswitches

Albert, L.; Peñalver, A.; Djokovic, N.; Were, L.; Hoffarth, M.; Ruzic, D.; Xu, J.; Essen, L.-O.; Nikolic, K.; Dou, Y.; Vázquez, O.*

ChemBioChem, 2019, 20, 1417-1429.

Contribution to the Special ChemBioTalents Themed Issue in ChemBioChem

ortho-Fluoroazobenzene derivatives as DNA intercalators for photocontrol of DNA and nucleosome binding by visible light

Heinrich, B.; Bouazoune, K.; Wojcik, M.; Bakowsky, U.; Vázquez, O.*

Org. Biomol. Chem., 2019, 17, 1827-1833

Contribution to the Special New Talent Themed Issue in Organic & Biomolecular Chemistry 


A Far-red fluorescent DNA binder for interaction studies of live multidrug-resistant pathogens and host cells

Schulte, L. N.; Heinrich, B.; Janga, H.; Schmeck, B. T.; Vázquez, O.*

Angew. Chem. Int. Ed. Engl., 2018, 57, 11564-11568

Controlled inhibition of methyltransferases using photoswitchable peptidomimetics: towards an epigenetic regulation of leukemia

Albert, L.; Xu, J.; Wan, R.; Srinivasan, V.; Dou, Y. Vázquez, O.*

Chem. Sci., 2017, 8, 4612-4618

Potential of proapoptotic peptides to induce formation of giant plasma membrane vesicles with lipide domains

Lauster, D.; Vázquez, O.; Schwarzer, R.; Herrmann, A.; Seitz, O. *

ChemBioChem., 2015, 16, 1288-1292   


Cytotoxic peptide-PNA conjugates by RNA-programmed peptidyl transfer with turnover

Vázquez, O.; Seitz, O. *

Chem Sci., 2014, 5, 2850-2854

Templated native chemical ligation: peptide chemistry beyond protein synthesis

Vázquez, O.; Seitz, O *

J. Pept., 2014, 20, 78-86

The ββα fold of zinc finger proteins as a “natural” protecting group. Chemoselective synthesis of a DNA-binding zinc finger derivative

Rodríguez, J.; Mosquera, J.; Vázquez, O.; Vázquez, M. E.; Mascareñas J. L. *

Chem. Commun, 2014, 50, 2258-2260


Sequence-selective DNA recognition with peptide-bisbenzamidine conjugates

Sánchez, M. I.; Vázquez, O.; Vázquez, M. E.; Mascareñas J. L. *

Chem. Eur. J., 2013, 19, 9923-9929

Straightforward access to bisbenzamidine DNA binders and their use as versatile adaptors for DNA-promoted processes

Sánchez, M. I.; Vázquez, O.; Martínez-Costas, J.; Vázquez, M. E.; Mascareñas J. L *

Chem. Sci, 2012, 3, 2383-2387


Light-controlled DNA binding of bisbenzamidines

Sánchez, M. I.; Vázquez , O.; V?zquez. M. E.; Mascareñas, J.L. *

Chem. Commun., 2011, 47, 11107-11109


dsDNA-triggered energy transfer and lanthanide sensitization processes

Vázquez , O.; Sánchez, M. I.; Vázquez. M. E.; Mascareñas, J.L. *

Chem. Commun., 2010, 46, 5518-5520

Bis-4-aminobenzamidines: versatile, fluorogenic A/T selective dsDNA binders

Vázquez, O.; Sánchez, M. I.; Martínez Costas, J.; Vázquez. M. E.; Mascareñas, J.L. *

Org. Lett. 2010, 12, 216-219

Peptide-based fluorescent biosensors.

Pazos, E.; Vázquez, O. Mascareñas, J. L. *; Vázquez, M. E *

Chem. Soc. Rev. 2009, 38, 3348-3359

Efficient DNA binding and nuclear uptake by distamycin derivates conjugated to octa-arginine sequences

Vázquez, O.; Blanco, J.B; Vázquez, M. E.; Martinez-Costas, J. Castedo, L.; Mascareñas, J.L. *


ChemBioChem. 2008, 9, 2822-2829

Specific DNA recognition by a synthetic, monomeric Cys2His2 zinc finger peptide conjugated to a minor groove binder

Vázquez, O.; Vázquez, M. E.; Blanco, J. B.; Castedo, L.; Mascareñas, J.L. *

Angew. Chem. Int. Ed. Engl., 2007, 46, 6886–6890


High affinity, sequence specific DNA-binding by synthetic tripyrrole-peptide conjugates

Blanco, J.B; Vázquez, O.; Martinez-Costas, J.; Castedo, L.; Mascareñas, J.L *

Chem. Eur. J. 2005, 11, 4171-4178