Cell Report Paper Accepted
ACS Central Science – Accepted!!!
Happy to contribute to this fantastic work of Brehm Lab at Marburg University. Such interaction would not be possible without our TRR81 Chromatin Changes in Differentiation and Malignancies. Congrats to to Ikram & all authors. From our side, credits go to our Lea!
PNAs enable miR-155 inhibition in macrophages
An advanced Xmas present! Our Conformationally Strained Visible light Photoswitches (CS-VIPs) are genuine binary functional switches that enable hematopoisis photocontrol in zebrafish by releasing the chromatin modifier MLL1. An heroic mutidisciplinary effort in pandemic times!! We made it, Lea! Thank you everybody.
PLOS Genetics Paper Is Out!!
We achieve manipulation of primary cells without compromising viability by PNA-conjugates. Check our RNA Biology paper of Greta. Congrats, Greta! Well-deserved! Excellent collaboration with Schulte’s Lab.
It is a great pleasure to contribute to this brilliant story of Jonathan Lenz & Alexander Brehm. Exciting science arises from our collaborative TRR81 Chromatin Changes in Differentiation and Malignancies
Our TRR81 lockdown paper is online! We review the fetal hemoglobin repression network focused on epigenetic repressors that could be targeted by PROTACs. Excellent teamwork with Sjaak Philipsen. Kudos to Thijs & Marco! You can find this article in the Chemical Epigenetics Issue.
Top 10% Most Downloaded Paper!
We are thrilled to share our new paper in Chemistry—An European Journal. We have implemented a peptide‐based platform to prepare, and confine bioorthogonally activatable BODIPY-tetrazine photosensitizers. Check out our cytoplasmic membrane derivative, quite impressive! Congrats to Greta, you rock!
Our ChemBio Course Is Published in J. Chem. Educ.
As Whitesides said “Interesting & unpublished is equivalent to non-existent”. We believe that published & unread does not make it any better. We publish to share our findings and achieve a collective advancement in science. Therefore, we are thrilled that our work on photoswitchable protein-protein interaction (PPI) modulators belongs to the 2019 top downloaded ChemBioChem […]
Mild Synthetic Approach for DNA-binding Polyamides
We describe an integrative chemical biology course focused on epigenetics. We strive to bring research culture to chemistry and biology Master’ s students. This article represents our compromise to become a teaching scholar as well as the courage to step out of our comfort zone. Touching teaching paper for us! Visit naughtee.net. We hope this […]
Our First BJOC Is Online!!
We developed a solid phase peptide methodology based on the Mtt protecting group. Our strategy is orthogonal and compatible with sensitive molecules and could be ready automated. Besides, our building blocks to Eliquis are more accessible than the standard Fmoc and Boc SPPS ones. Congratulations to Bene! Well-done!
Our work on visible-light responsive peptide nucleic acids (PNAs) has been accepted in the Molecular Switches themed issue of the Beilstein Journal of Organic Chemistry! Alternative versions based on ours may open new venues in chemical biology, nanotechnology, material science. Congratulations to Lei (and Greta, of course!) Well-done!