Research

The passion for studying life by chemistry!

Our multidisciplinary research strives to understand biological processes at the molecular level to elucidate the fundamental problems at the interface of chemistry and biology. For this purpose, we focus on the design and development of innovative chemical tools for sensing biological processes and remotely manipulate molecular machines inside cells. Our work embraces the synthesis of low molecular weight drug-like molecules, peptides and nucleic acids combined with the methodology to investigate physiological responses. Thus, our optochemical tools have been able of achieving conditional and selective biological modulation by taking full advantage of photosensitive molecules



Fluorophores
Our  far-red compound 6-TramTO-3 enables fast and reliable fluorescent labelling of multi-resistant bacteria without  genetic modification.
Angew. Chem. Int. Ed. Engl., 2018, 57, 11564
Filed Patent: EP18174086.1
Photoswitches
Our optoepigenetic tools reversibly photomodulate either histone methyltransferase activity or nucleosome assembly.
Chem. Sci., 2017, 8, 4612  
Org. Biomol. Chem.2019, 17, 1827
Photosensitizers
Our novel halogenated BODIPY‐tetrazine probes simultaneously allows both specific subcellular localization  and conditional singlet oxygen generation.
Angew. Chem. Int. Ed. Engl. 2019, 58, 12868

About

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Meet our Team

Our passionate team makes the magic happen!
Ina Pinnschmidt
Ina Pinnschmidt

Administrative Assistant

Room: C104 (01/3040)
Tel: +49 6421 28 21535
Fax: +49 6421 28 22189

Van Tuan Trinh (Marco)
Van Tuan Trinh (Marco)

PhD Student

Room: D264 (02/4640) Tel: +49 6421 28 21819 Interests: peptides & epigenetics

Lea Albert
Lea Albert

PhD student

Room: D264 (02/4640)
Tel: +49 6421 28 22747
Interests: photoswitches & histone methyltransferases

Greta Linden
Greta Linden

PhD Student

Room: D264 (02/4640)
Tel: +49 6421 28 22747
Interests: photosensitizers & peptide nucleic acids (PNAs)

Lei Zhang
Lei Zhang

PhD Student

Room: D264 (02/4640)
Tel: +49 6421 282 2748
Interests: photoswitches & photosensitizers

Laura Hillebrand
Laura Hillebrand

Master Student

Room: D264 (02/4640)
Tel: +49 6421 28 22748
Interests: photoreactive amino acids

Carl J. Weile
Carl J. Weile

Master Student

Room: D264 (02/4640)
Tel: +49 6421 28 22747
Interests: template reactions

    Address
    Fachbereich Chemie Philipps-Universität Marburg Hans-Meerwein-Straße 4, Second floor D 233 (02/4330 D-35043 Marburg Germany
    Phone & Email
    E-mail: olalla.vazquez@staff.uni-marburg.de Phone: +49-6421-28-22745