Research

The passion for studying life by chemistry!

Our multidisciplinary research strives to understand biological processes at the molecular level to elucidate the fundamental problems at the interface of chemistry and biology. For this purpose, we focus on the design and development of innovative chemical tools for sensing biological processes and remotely manipulate molecular machines inside cells. Our work embraces the synthesis of low molecular weight drug-like molecules, peptides and nucleic acids combined with the methodology to investigate physiological responses. Thus, our optochemical tools have been able of achieving conditional and selective biological modulation by taking full advantage of photosensitive molecules



Fluorophores
Our  far-red compound 6-TramTO-3 enables fast and reliable fluorescent labelling of multi-resistant bacteria without  genetic modification.
Angew. Chem. Int. Ed. Engl., 2018, 57, 11564
Filed Patent: EP18174086.1
Photoswitches
Our optoepigenetic tools reversibly photomodulate either histone methyltransferase activity or nucleosome assembly.
Chem. Sci., 2017, 8, 4612  
Org. Biomol. Chem.2019, 17, 1827
Photosensitizers
Our novel halogenated BODIPY‐tetrazine probes simultaneously allows specific subcellular localization  and conditional singlet oxygen generation.
Angew. Chem. Int. Ed. Engl. 2019, 58, 12868
Chemistry2020, 26, 10014

About

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Meet our Team

Our passionate team makes the magic happen!
Ina Pinnschmidt
Ina Pinnschmidt

Administrative Assistant

Room: C104 (01/3040)
Tel: +49 6421 28 21535
Fax: +49 6421 28 22189

    Van Tuan Trinh (Marco)
    Van Tuan Trinh (Marco)

    PhD Student

    Room: D264 (02/4640)
    Tel: +49 6421 28 21819 Interests: peptides & epigenetics

      Björn Hanf
      Björn Hanf

      Master Student

      Room: D264 (02/4640)
      Tel: +49 6421 28 22747 Interests: bacteria labelling

        Greta Linden
        Greta Linden

        PhD Student

        Room: D264 (02/4640)
        Tel: +49 6421 28 22747
        Interests: photosensitizers & peptide nucleic acids (PNAs)

          Lei Zhang
          Lei Zhang

          PhD Student

          Room: D264 (02/4640)
          Tel: +49 6421 282 2748
          Interests: photoswitches & photosensitizers

            Laura Hillebrand
            Laura Hillebrand

            Master Student

            Room: D264 (02/4640)
            Tel: +49 6421 28 22748
            Interests: photoreactive amino acids

              Anett Hauser
              Anett Hauser

              Postdoc Student


              Room: D264 (02/4640)
              Tel: +49 6421 28 22747
              Interests: template reactions

                Address
                Fachbereich Chemie Philipps-Universität Marburg Hans-Meerwein-Straße 4, Second floor D 233 (02/4330) 35043 Marburg Germany
                Phone & Email
                E-mail: olalla.vazquez@staff.uni-marburg.de Phone: +49-6421-28-22745